Effective prophylactic protocol in delayed hypersensitivity to contrast media: report of a case involving lymphocyte transformation studies with different compounds

Radiology. 2002 Nov;225(2):466-70. doi: 10.1148/radiol.2251011654.

Abstract

A patient with maculopapular reactions to iopamidol needed to undergo angiography for a cerebral arteriovenous malformation. In vivo and in vitro tests were performed with ionic and nonionic contrast media, including iopamidol and iobitridol. All results were positive, demonstrating delayed hypersensitivity. The patient received 6-alpha-methylprednisolone and cyclosporine 1 week before and 2 weeks after four angiograms were obtained with the use of iobitridol, which was well tolerated.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cerebral Angiography*
  • Contrast Media / adverse effects*
  • Cyclosporine / administration & dosage*
  • Drug Eruptions / diagnosis
  • Drug Eruptions / immunology
  • Drug Eruptions / prevention & control*
  • Embolization, Therapeutic
  • Humans
  • Hypersensitivity, Delayed / diagnosis
  • Hypersensitivity, Delayed / immunology
  • Hypersensitivity, Delayed / prevention & control*
  • Immunosuppressive Agents / administration & dosage*
  • Intracranial Arteriovenous Malformations / diagnostic imaging*
  • Intracranial Arteriovenous Malformations / therapy
  • Intradermal Tests
  • Iohexol / adverse effects
  • Iohexol / analogs & derivatives*
  • Iopamidol / adverse effects*
  • Iopamidol / immunology
  • Lymphocyte Activation / immunology*
  • Male
  • Methylprednisolone / administration & dosage*
  • Patch Tests
  • Premedication
  • Retreatment

Substances

  • Contrast Media
  • Immunosuppressive Agents
  • iobitridol
  • Iohexol
  • Cyclosporine
  • Iopamidol
  • Methylprednisolone