Abstract
Three new biphenyl type diarylheptanoid glycosides, myricanol 11-O-beta-D-glucopyranoside, myricanone 5-O-beta-D-glucopyranoside, and neomyricanone 5-O-beta-D-glucopyranoside, and a new taraxerane type triterpene, myricetrione, were isolated from the bark of Chinese Myrica rubra. Their structures were elucidated on the basis of chemical and physicochemical evidence. Biphenyl type diarylheptanoids, triterpene, and their polyphenols showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-activated macrophages. Furthermore, diarylheptanoids, myricanol and myricanone, were found to inhibit induction of inducible nitric oxide synthase.
MeSH terms
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Animals
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Biphenyl Compounds
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Diarylheptanoids / chemistry
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Diarylheptanoids / isolation & purification
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Diarylheptanoids / pharmacology
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Drugs, Chinese Herbal / chemistry
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Macrophages, Peritoneal / drug effects
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Macrophages, Peritoneal / enzymology
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Macrophages, Peritoneal / metabolism
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Mice
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Molecular Structure
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Myrica / chemistry*
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide Synthase / antagonists & inhibitors
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Nitric Oxide Synthase Type II
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Plant Bark / chemistry
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
Substances
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Biphenyl Compounds
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Diarylheptanoids
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Drugs, Chinese Herbal
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Glycosides
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Triterpenes
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myricetrione
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Nitric Oxide
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myricanone
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myricanol
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse