7-Methoxy-1H-indazole, a new inhibitor of neuronal nitric oxide synthase

Acta Crystallogr C. 2002 Nov;58(Pt 11):o688-90. doi: 10.1107/s0108270102017948. Epub 2002 Oct 31.

Abstract

The crystal structure of 7-methoxy-1H-indazole, C(8)H(8)N(2)O, an inhibitor of nitric oxide synthase, shows that the methoxy group lies in the plane of the indazole system with its methyl group located trans to the indazole N-H group. The crystal packing consists principally of hydrogen-bonded trimers. Intermolecular hydrogen-bonding interactions are formed between the indazole N atoms, with the N-H group as a hydrogen-bond donor and the remaining N atom as an acceptor.

MeSH terms

  • Crystallography, X-Ray
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Hydrogen Bonding
  • Indazoles / chemistry
  • Indazoles / pharmacology*
  • Models, Molecular
  • Molecular Structure
  • Nitric Oxide Synthase / antagonists & inhibitors*
  • Nitric Oxide Synthase Type I

Substances

  • 7-methoxyindazole
  • Enzyme Inhibitors
  • Indazoles
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type I