[The hyperplasia-adenoma sequence: a case supporting this hypothesis]

Pathologica. 2002 Oct;94(5):234-7. doi: 10.1007/s102420200038.
[Article in Italian]

Abstract

We described the morphological, histochemical and immunohistochemical findings of a polyp detected in the left colon (splenic flexure) in which the diagnosis was atypical hyperplastic polyp. The description is focused on the capability of a hyperplastic polyp to evolve into adenomatous tissue through different modalities.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adenoma / chemistry
  • Adenoma / pathology*
  • Biomarkers, Tumor / analysis
  • Colon / metabolism
  • Colon / pathology*
  • Colonic Neoplasms / chemistry
  • Colonic Neoplasms / pathology*
  • Colonic Polyps / chemistry
  • Colonic Polyps / pathology*
  • Disease Progression
  • Humans
  • Hyperplasia
  • Intermediate Filament Proteins / analysis
  • Intestinal Mucosa / metabolism
  • Intestinal Mucosa / pathology*
  • Keratin-20
  • Ki-67 Antigen / analysis
  • Male
  • Middle Aged
  • Proto-Oncogene Proteins c-bcl-2 / analysis
  • Tumor Suppressor Protein p53 / analysis

Substances

  • Biomarkers, Tumor
  • Intermediate Filament Proteins
  • KRT20 protein, human
  • Keratin-20
  • Ki-67 Antigen
  • Proto-Oncogene Proteins c-bcl-2
  • Tumor Suppressor Protein p53