Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives

Neelam Bharti; Kakul Husain; M T Gonzalez Garza; Delia E Cruz-Vega; J Castro-Garza; Benito D Mata-Cardenas; Fehmida Naqvi; Amir Azam

doi:10.1016/s0960-894x(02)00703-5

Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3475-8. doi: 10.1016/s0960-894x(02)00703-5.

Authors

Neelam Bharti¹, Kakul Husain, M T Gonzalez Garza, Delia E Cruz-Vega, J Castro-Garza, Benito D Mata-Cardenas, Fehmida Naqvi, Amir Azam

Affiliation

¹ Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.

PMID: 12419387
DOI: 10.1016/s0960-894x(02)00703-5

Abstract

Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N(4)-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry*
Aldehydes / pharmacology
Amines / chemistry
Animals
Antiprotozoal Agents / chemical synthesis*
Antiprotozoal Agents / pharmacology*
Entamoeba histolytica / drug effects
Giardia lamblia / drug effects
Inhibitory Concentration 50
Parasitic Sensitivity Tests
Structure-Activity Relationship
Sulfhydryl Compounds / chemistry*
Sulfhydryl Compounds / pharmacology
Thiosemicarbazones / chemistry*
Thiosemicarbazones / pharmacology*
Trichomonas vaginalis / drug effects

Substances

Aldehydes
Amines
Antiprotozoal Agents
Sulfhydryl Compounds
Thiosemicarbazones