Duplication 15q as the sole anomaly in an acute promyelocytic leukemia patient without t(15;17)

Lijun Zhang; John J Mulvihill; William F Kern; Johnny McMinn; Shibo Li

doi:10.1016/s0165-4608(02)00538-1

Duplication 15q as the sole anomaly in an acute promyelocytic leukemia patient without t(15;17)

Cancer Genet Cytogenet. 2002 Oct 1;138(1):17-21. doi: 10.1016/s0165-4608(02)00538-1.

Authors

Lijun Zhang¹, John J Mulvihill, William F Kern, Johnny McMinn, Shibo Li

Affiliation

¹ Department of Pediatrics, Health Sciences Center, University of Oklahoma, Oklahoma City, OK 73104, USA.

PMID: 12419579
DOI: 10.1016/s0165-4608(02)00538-1

Abstract

We present a unique chromosomal abnormality found in a patient with acute myeloblastic leukemia of French-American-British subtype M3. The patient was referred for an evaluation of a chromosomal anomaly exclusively associated with FAB M3 or acute promyelocytic leukemia: a translocation between chromosomes 15 and 17, t(15;17)(q22;q21.1). Neither t(15;17) nor rearrangement of RARalpha was detected by routine G-banded chromosome as well as fluorescence in situ hybridization analysis using the commercial dual-color PML/RARalpha translocation probe and the RARalpha probe, a break apart rearrangement dual-color probe. Instead of the typical rearrangement between chromosomes 15 and 17, all cells analyzed had a duplication of the segment of chromosome 15 between bands 15q15 and 15q26.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bone Marrow / pathology
Chromosomes, Human, Pair 15 / genetics*
Chromosomes, Human, Pair 17*
Gene Duplication*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology
Male
Translocation, Genetic*