Abstract
It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.
MeSH terms
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Adenocarcinoma / genetics
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Adenocarcinoma / pathology*
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Adenoma / genetics
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Adenoma / pathology*
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Adenomatous Polyposis Coli Protein / physiology
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Animals
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Cell Movement
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Cell Transformation, Neoplastic / pathology*
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Colonic Neoplasms / genetics
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Colonic Neoplasms / pathology*
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Epithelial Cells / cytology
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Genes, APC
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Humans
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Intestinal Mucosa / cytology*
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Models, Biological
Substances
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Adenomatous Polyposis Coli Protein