Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia

Roger G Linington; Marilyn Robertson; Annick Gauthier; B Brett Finlay; Rob van Soest; Raymond J Andersen

doi:10.1021/ol0268337

Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia

Org Lett. 2002 Nov 14;4(23):4089-92. doi: 10.1021/ol0268337.

Authors

Roger G Linington¹, Marilyn Robertson, Annick Gauthier, B Brett Finlay, Rob van Soest, Raymond J Andersen

Affiliation

¹ Department of Chemistry, University of British Columbia, Vancouver, B.C., V6T 1Z1, Canada.

PMID: 12423093
DOI: 10.1021/ol0268337

Abstract

Extracts of the marine sponge Caminus sphaeroconia showed potent activity in a screen for bacterial type III secretion inhibitors. Bioassay guided fractionation of the extract led to the isolation of the novel antimicrobial glycolipid caminoside A (1). The structure of caminoside A was elucidated by analysis of spectroscopic data and chemical degradation.[structure: see text]

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification*
Carbohydrate Conformation
Cyclobutanes / chemical synthesis*
Cyclobutanes / chemistry
Glucose / chemistry
Glycolipids / chemistry
Glycolipids / isolation & purification*
Models, Molecular
Molecular Structure
Porifera / chemistry*
Sulfonamides / chemical synthesis*
Sulfonamides / chemistry

Substances

Anti-Infective Agents
Cyclobutanes
Glycolipids
Sulfonamides
triethylmethylsulfinamide
Glucose
sibutramine