Abstract
Employing modified oligonucleotides that are 4'-alkylated site-specifically we investigated the involvement of DNA minor groove hydration on DNA duplex stability and helix conformation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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DNA / chemistry*
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DNA / ultrastructure
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Molecular Probes / chemical synthesis
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Molecular Probes / chemistry
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Nucleic Acid Conformation
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Nucleic Acid Denaturation
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Oligonucleotides / chemical synthesis
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Oligonucleotides / chemistry
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Temperature
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Thymidine
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Water / chemistry*
Substances
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Molecular Probes
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Oligonucleotides
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Water
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DNA
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Thymidine