Modification of post-PKS tailoring steps through combinatorial biosynthesis

Nat Prod Rep. 2002 Oct;19(5):542-80. doi: 10.1039/b103920m.

Abstract

This review covers the highlights of combinatorial biosynthesis applied on post-polyketide synthase modifying enzymes, such as oxygenases. ketoreductases, glycosyl- and methyltransferases, acyltransferases, halogenases, cyclases and aminotransferases Since this is the first review on this topic, it covers literature from 1985 to 2002, and 248 references are given.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Combinatorial Chemistry Techniques
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Multienzyme Complexes / biosynthesis
  • Multienzyme Complexes / chemistry*
  • Multienzyme Complexes / classification
  • Multienzyme Complexes / metabolism
  • Oxidoreductases
  • Transferases / metabolism

Substances

  • Multienzyme Complexes
  • Oxidoreductases
  • Transferases