Abstract
Drug addiction has been linked to protracted functional changes in neural circuits involved in motivation that can lead to drug dependence, craving and relapse. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signal transduction pathway in long-lasting behavioral sensitization to cocaine in rats, an animal model of the long-lasting functional changes induced by repeated drug use. Our results show that PI3K is required for the expression, but not the induction, of behavioral sensitization to cocaine.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Behavior, Animal / physiology
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Brain / drug effects*
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Brain / enzymology*
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Brain / physiopathology
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Chromones / pharmacology
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Cocaine / pharmacology*
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Cocaine-Related Disorders / enzymology*
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Cocaine-Related Disorders / physiopathology
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Disease Models, Animal
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Enzyme Inhibitors / pharmacology
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Male
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Morpholines / pharmacology
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Motor Activity / drug effects
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Motor Activity / physiology
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Neuronal Plasticity / drug effects*
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Neuronal Plasticity / physiology
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Neurons / drug effects*
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Neurons / enzymology*
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Phosphatidylinositol 3-Kinases / drug effects*
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Phosphatidylinositol 3-Kinases / metabolism
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Rats
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Rats, Wistar
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Signal Transduction / drug effects
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Signal Transduction / physiology
Substances
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Chromones
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Enzyme Inhibitors
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Morpholines
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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Phosphatidylinositol 3-Kinases
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Cocaine