Survival of Ugandan infants with subtype A and D HIV-1 infection (HIVNET 012)

J Acquir Immune Defic Syndr. 2002 Nov 1;31(3):327-30. doi: 10.1097/00126334-200211010-00009.

Abstract

Virologic factors may influence survival of HIV-1-infected infants. We compared survival of Ugandan infants with subtype A and subtype D HIV-1 infection. This study was performed in the context of the Ugandan clinical trial HIVNET 012, which compared the efficacy of single-dose nevirapine (NVP) and short-course zidovudine (AZT) for prevention of HIV-1 mother-to-child transmission. HIV-1 subtypes were determined by phylogenetic analysis of HIV-1 protease and reverse transcriptase sequences from 32 women in the NVP arm and 54 women in the AZT arm of HIVNET 012 whose infants were HIV-1 infected by 6 to 8 weeks of age. We found no association between HIV-1 subtype (A vs. D) and infant survival in this cohort. Further studies are needed to evaluate whether HIV-1 subtype influences clinical outcome in pediatric HIV-1 infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cohort Studies
  • Female
  • Genotype
  • HIV Infections / drug therapy
  • HIV Infections / mortality*
  • HIV Infections / transmission
  • HIV Infections / virology*
  • HIV-1* / classification
  • HIV-1* / genetics
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical
  • Molecular Sequence Data
  • Nevirapine / therapeutic use
  • Phylogeny
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy
  • Survival Rate
  • Uganda / epidemiology
  • Zidovudine / therapeutic use

Substances

  • Zidovudine
  • Nevirapine

Associated data

  • GENBANK/AF410203
  • GENBANK/AF410204
  • GENBANK/AF410205
  • GENBANK/AF410206
  • GENBANK/AF410207
  • GENBANK/AF410208
  • GENBANK/AF410209
  • GENBANK/AF410210
  • GENBANK/AF410211
  • GENBANK/AF410212
  • GENBANK/AF410213
  • GENBANK/AF410214
  • GENBANK/AF410215
  • GENBANK/AF410216
  • GENBANK/AF410217
  • GENBANK/AF410218
  • GENBANK/AF410219
  • GENBANK/AF410220
  • GENBANK/AF410221
  • GENBANK/AF410222
  • GENBANK/AF410223
  • GENBANK/AF410224
  • GENBANK/AF410225
  • GENBANK/AF410226
  • GENBANK/AF410227
  • GENBANK/AF410228
  • GENBANK/AF410229
  • GENBANK/AF410230
  • GENBANK/AF410231
  • GENBANK/AF410232
  • GENBANK/AF410233
  • GENBANK/AF410234
  • GENBANK/AF410235
  • GENBANK/AF410236
  • GENBANK/AF410237
  • GENBANK/AF410238
  • GENBANK/AF410239
  • GENBANK/AF410240
  • GENBANK/AF410241
  • GENBANK/AF410242
  • GENBANK/AF410243
  • GENBANK/AF410244
  • GENBANK/AF410245
  • GENBANK/AF410246
  • GENBANK/AF410247
  • GENBANK/AF410248
  • GENBANK/AF410249
  • GENBANK/AF410250
  • GENBANK/AF410251
  • GENBANK/AF410252
  • GENBANK/AF410253
  • GENBANK/AF410254
  • GENBANK/AF410255
  • GENBANK/AF410256