Synthesis and biological evaluation of novel 2-(1H-imidazol-4-yl)cyclopropane carboxylic acids: key intermediates for H3 histamine receptor ligands

Miguel F Braña; Cristina Guisado; Luis Fernando Alguacil; Elisa Garrido; Carmen Pérez-García; Mariano Ruiz-Gayo

doi:10.1016/s0960-894x(02)00793-x

Synthesis and biological evaluation of novel 2-(1H-imidazol-4-yl)cyclopropane carboxylic acids: key intermediates for H3 histamine receptor ligands

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3561-3. doi: 10.1016/s0960-894x(02)00793-x.

Authors

Miguel F Braña¹, Cristina Guisado, Luis Fernando Alguacil, Elisa Garrido, Carmen Pérez-García, Mariano Ruiz-Gayo

Affiliation

¹ Departamento de Ciencias Qui;micas, Sección de Qui;mica Orgánica y Farmacéutica, Universidad San Pablo CEU, Urb Montepríncipe, Boadilla del Monte 28668, Madrid, Spain. [email protected]

PMID: 12443776
DOI: 10.1016/s0960-894x(02)00793-x

Abstract

A new synthetic methodology to provide cis-2-(1H-imidazol-4-yl)-cyclopropane carboxylic acids is described. These cyclopropanes are useful for the preparation of novel H(3) receptor agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Chemistry
Carboxylic Acids / chemical synthesis
Carboxylic Acids / pharmacology
Cyclopropanes / chemical synthesis
Cyclopropanes / pharmacology
Histamine Antagonists / chemical synthesis*
Histamine Antagonists / pharmacology
Ligands
Methylhistamines / metabolism
Radioligand Assay
Rats
Receptors, Histamine H3 / drug effects*
Structure-Activity Relationship

Substances

Carboxylic Acids
Cyclopropanes
Histamine Antagonists
Ligands
Methylhistamines
Receptors, Histamine H3