Unique hole-trapping property of the degenerate base,2-amino-7-deazaadenine

Akimitsu Okamoto; Kazuo Tanaka; Isao Saito

doi:10.1016/s0960-894x(02)00661-3

Unique hole-trapping property of the degenerate base,2-amino-7-deazaadenine

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3641-3. doi: 10.1016/s0960-894x(02)00661-3.

Authors

Akimitsu Okamoto¹, Kazuo Tanaka, Isao Saito

Affiliation

¹ Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.

PMID: 12443793
DOI: 10.1016/s0960-894x(02)00661-3

Abstract

An artificial degenerate nucleobase, 2-amino-7-deazaadenine (1) showed remarkably high hole-trapping efficiency, similar to that of (Z)G and superior to that of the GGG triplet. The hole-trapping efficiency varied with the counterbase that base-pairs with 1.

MeSH terms

Adenine / analogs & derivatives*
Adenine / chemistry*
Base Pairing
Base Sequence
DNA Damage
Hydrolysis
Oligonucleotides / chemistry*
Oxidation-Reduction

Substances

2-amino-7-deazaadenine
Oligonucleotides
Adenine