Scoring of treatment-related late effects in prostate cancer

Radiother Oncol. 2002 Nov;65(2):109-21. doi: 10.1016/s0167-8140(02)00286-4.

Abstract

Background and purpose: To assess the correlation between different general and organ specific quality of life and morbidity scoring methods in a cohort of men treated with radical radiotherapy for prostate cancer.

Materials and methods: Men who had been treated with radical radiotherapy (50 Gy in 16 fractions over 21 days) for localized prostate cancer more than 3 years previously and who had no evidence of recurrent disease were invited to take part in the study. A total of 101 of 135 invited patients agreed and completed LENT/SOMA, UCLA Prostate Cancer Index, and 36 item RAND Health survey questionnaires.

Results: The patients had comparable results with other published series with respect to the UCLA and SF-36 indices. There was significant correlation between the corresponding parts of the UCLA and LENT/SOMA scales (P<0.0005). However, for the same symptoms, a patient tended to score lower (worse) on the UCLA scale in comparison to LENT/SOMA. The relationship between the average LENT/SOMA score and maximum score was also not straightforward with each set of data revealing different information.

Conclusions: The LENT/SOMA questions were, in the main, more wide-ranging and informative than the UCLA index. It is helpful to give both the overall and maximum LENT/SOMA scores to most efficiently use all of the data. There may need to be a further LENT/SOMA question to allow both symptoms of tenesmus and faecal urgency to be fully addressed.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Humans
  • Inflammatory Bowel Diseases / etiology
  • Male
  • Middle Aged
  • Prostatic Neoplasms / psychology*
  • Prostatic Neoplasms / radiotherapy*
  • Quality of Life / psychology
  • Radiotherapy, Conformal / adverse effects*
  • Sexual Dysfunction, Physiological / etiology
  • Sickness Impact Profile*
  • Surveys and Questionnaires
  • Time Factors
  • Urinary Bladder Diseases / etiology