Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger

Ji-Xun Zhan; Yuan-Xing Zhang; Hong-Zhu Guo; Jian Han; Li-Li Ning; De-An Guo

doi:10.1021/np020113r

Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger

J Nat Prod. 2002 Nov;65(11):1693-5. doi: 10.1021/np020113r.

Authors

Ji-Xun Zhan¹, Yuan-Xing Zhang, Hong-Zhu Guo, Jian Han, Li-Li Ning, De-An Guo

Affiliation

¹ The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China.

PMID: 12444705
DOI: 10.1021/np020113r

Abstract

Artemisinin (1) was transformed by Mucor polymorphosporus and Aspergillus niger. Five products were identified as 9beta-hydroxyartemisinin (2), 3beta-hydroxyartemisinin (3), deoxyartemisinin (4), 3beta-hydroxydeoxyartemisinin (5), and 1alpha-hydroxydeoxyartemisinin (6). Products 2, 3, and 6 are new compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Artemisinins / metabolism*
Aspergillus niger / metabolism*
Catalysis
China
Magnetic Resonance Spectroscopy
Molecular Structure
Mucor / metabolism*
Sesquiterpenes / metabolism*

Substances

Artemisinins
Sesquiterpenes
artemisinin