Abstract
A new (2) and three known diarylheptanoids (1, 3, and 4), along with one known sesquiterpenoid (5), were isolated from the roots of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. Four of these compounds (2-5) exhibited moderate cytotoxicities against human colon carcinoma and human lung carcinoma cell lines with IC(50)'s ranging from 2 to 25 microg/mL.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Cell Survival / drug effects
-
Colonic Neoplasms
-
Diarylheptanoids / chemistry
-
Diarylheptanoids / isolation & purification*
-
Diarylheptanoids / pharmacology
-
Drug Screening Assays, Antitumor
-
Humans
-
Inhibitory Concentration 50
-
Juglans / chemistry*
-
Korea
-
Lung Neoplasms
-
Medicine, Traditional
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plants, Medicinal / chemistry*
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification*
-
Sesquiterpenes / pharmacology
-
Tumor Cells, Cultured / drug effects
Substances
-
Antineoplastic Agents, Phytogenic
-
Diarylheptanoids
-
Sesquiterpenes