The presence of progestational diabetes mellitus, type 1 or type 2, in pregnant women has been associated with adverse effects on maternal and neonatal outcomes. The incidence of obstetrical and metabolic complications is increased, and a continuum has been observed between maternal blood glucose levels and perinatal outcome: perinatal mortality, severe congenital malformations, prematurity, macrosomia. Elective delivery is considered at 38-39 weeks of gestation in an appropriate perinatal center with a pre-established protocol in order to maintain euglycemia. Pre-conceptional programming and intensive collaborative follow-up of such pregnancies improve the outcome of such pregnancies.