Epstein-Barr virus-associated T-cell lymphoma: a case of eyelid swelling and intramuscular infiltration mimicking dermatomyositis

Br J Dermatol. 2002 Dec;147(6):1244-8. doi: 10.1046/j.1365-2133.2002.05037.x.

Abstract

Association with Epstein-Barr virus (EBV) infection has been noted in various types of cutaneous lymphoproliferative disorders. We report a 57-year-old Japanese woman with T-cell lymphoma mimicking dermatomyositis that was associated with chronic active EBV infection. She presented with low-grade fever, bilateral erythematous swellings on the eyelids, and necrotic papules on the face. Serum creatine kinase levels were elevated and a diffuse reticular shadow was detected in both lung fields. The infiltrate of atypical lymphocytes found in skin and muscle, which contained EBV-encoded small nuclear RNA-1 and EBV, was also detected in the CD4+ peripheral blood cells. Treatment with prednisolone resolved her lesions with no relapse for 3 years, after which there was a recurrence in her left lung. Combination chemotherapy was not effective against the lung lesion and she died with multiple organ failure 2 months after the recurrence.

Publication types

  • Case Reports

MeSH terms

  • Dermatomyositis / diagnosis*
  • Diagnosis, Differential
  • Edema / virology
  • Epstein-Barr Virus Infections / complications*
  • Eyelid Diseases / virology
  • Female
  • Humans
  • Lymphoma, T-Cell, Cutaneous / diagnosis*
  • Lymphoma, T-Cell, Cutaneous / virology
  • Middle Aged
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / virology