Abstract
From 1996 to 2000, 23 Maryland and Washington, D.C., tuberculosis cases were identified in one six-band DNA cluster. Cases were clustered on the basis of their Mycobacterium tuberculosis isolates. Medical record reviews and interviews were conducted to identify epidemiologic linkages. Eighteen (78%) of the 23 case-patients with identical restriction fragment length polymorphism patterns were linked to another member; half the patients were associated with a Washington, D.C., homeless shelter. Molecular epidemiology defined the extent of this large, cross-jurisdictional outbreak.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Cluster Analysis
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Disease Outbreaks
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District of Columbia / epidemiology
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Female
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Genotype
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Humans
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Ill-Housed Persons*
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Male
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Maryland / epidemiology
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Middle Aged
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Molecular Epidemiology
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Mycobacterium tuberculosis / classification
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / isolation & purification*
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Polymorphism, Restriction Fragment Length
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Risk Factors
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Time Factors
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Tuberculosis / epidemiology*
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Tuberculosis / microbiology
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Tuberculosis / transmission*