[Results of the treatment of childhood acute lymphoblastic leukemia according to the Berlin-Moscow-91 protocol in 1991-2000]

N V Miakova; R Hartmann; A E Rudneva; N M Trubina; L G Fechina; A M Timakov; A V Shamardina; V V Lebedev; S R Varfolomeeva; S D Dudkin; Z M Dyshlevaia; V N Timofeeva; A G Rumiantsev; H Henze; A I Karachunskiĭ

[Results of the treatment of childhood acute lymphoblastic leukemia according to the Berlin-Moscow-91 protocol in 1991-2000]

Vopr Onkol. 2002;48(3):340-6.

[Article in Russian]

Authors

N V Miakova¹, R Hartmann, A E Rudneva, N M Trubina, L G Fechina, A M Timakov, A V Shamardina, V V Lebedev, S R Varfolomeeva, S D Dudkin, Z M Dyshlevaia, V N Timofeeva, A G Rumiantsev, H Henze, A I Karachunskiĭ

Affiliation

¹ Research Institute of Pediatric Hematology and Oncology, Ministry of Health of the RF, Russian Children's Clinical Hospital, Moscow.

PMID: 12455359

Abstract

The report deals with the results of application of an original protocol--the Berlin-Moscow-91 (BM-91)--for the treatment of acute lymphoblastic leukemia (ALL) in children. The researchers' major concern was to improve survival and cut down side-effects incidence as well as to prevent and successfully manage occult neuroleukemia as a potential source of relapse. Patients aged 5 months-15 years received the BM-91 and ALL BFM-90m treatment first at one clinic and later at several centers. Out of 852 children with primary diagnosis of ALL admitted to Russian hematological hospitals (March 2, 1991-November 3, 2000), 687 were included into the study; 329 received the MB-91 protocol. Nine-year recurrence-free survival was 73% while overall survival--80%. Toxic side-effects after L-asparaginase were reported in 27 (7.9%). It is concluded that good results in childhood ALL treatment can be achieved without resorting to high-dosage chemotherapy and radiation in most cases.

Publication types

Clinical Trial
Comparative Study
Multicenter Study
Randomized Controlled Trial

MeSH terms

Adolescent
Antimetabolites, Antineoplastic / administration & dosage
Antineoplastic Agents / administration & dosage
Antineoplastic Agents, Hormonal / administration & dosage
Antineoplastic Agents, Phytogenic / administration & dosage
Antineoplastic Combined Chemotherapy Protocols*
Asparaginase / administration & dosage
Child
Child, Preschool
Cytarabine / administration & dosage
Data Interpretation, Statistical
Daunorubicin / administration & dosage
Dexamethasone / administration & dosage
Female
Follow-Up Studies
Humans
Infant
Male
Mercaptopurine / administration & dosage
Methotrexate / administration & dosage
Moscow
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
Remission Induction
Risk Factors
Russia
Survival Analysis
Time Factors
Vincristine / administration & dosage

Substances

Antimetabolites, Antineoplastic
Antineoplastic Agents
Antineoplastic Agents, Hormonal
Antineoplastic Agents, Phytogenic
Cytarabine
Vincristine
Dexamethasone
Mercaptopurine
Asparaginase
Methotrexate
Daunorubicin