Abstract
Rats selected by predisposition to catalepsy showed decreased level of 2A-serotonin receptor mRNA in the frontal cortex in comparison with Wistar rats (p<0.05). Chronic administration of tricyclic antidepressant imipramine hydrochloride 2-fold increased the content of receptor mRNA in genetically cataleptic rats (p<0.001) and did not change this parameter in Wistar rats. These results prompted us to revise current notion on the mechanisms of chronic effect of imipramine on 2A-serotonin receptors.
MeSH terms
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Animals
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Antidepressive Agents, Tricyclic / administration & dosage
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Antidepressive Agents, Tricyclic / pharmacology*
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Base Sequence
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Catalepsy / genetics*
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Cerebral Cortex / drug effects*
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Cerebral Cortex / metabolism
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DNA Primers
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Genetic Predisposition to Disease
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Imipramine / administration & dosage
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Imipramine / pharmacology*
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Male
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RNA, Messenger / genetics*
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RNA, Messenger / metabolism
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Rats
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Receptor, Serotonin, 5-HT2A
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Receptors, Serotonin / genetics*
Substances
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Antidepressive Agents, Tricyclic
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DNA Primers
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RNA, Messenger
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Receptor, Serotonin, 5-HT2A
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Receptors, Serotonin
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Imipramine