Remodeling of the myocardium during focal metabolic damages to cardiomyocytes is determined by contracture injuries to myofibrils, their lump degradation, and development of coagulation necrosis. Reactive changes in the stroma develop over the first hours and manifest in acute hemodynamic disturbances followed by proliferation of connective tissue cells. The immature granulation tissue is formed at the site of myocardial damages. Later this tissue is replaced by the mature connective tissue with the formation of small scars. It should be emphasized that sclerotic changes during remodeling of the myocardium after focal metabolic damages are reversible.