We used a total of 680 pigs to compare spray-dried blood meal and blood cells in nursery diets. In Exp. 1, 350 barrows (17 +/- 2 d of age at weaning) were used to compare three levels of spray-dried blood meal or blood cells (2.5, 5.0, and 7.5%) in the diet fed from d 5 to 19 postweaning (6.6 to 9.9 kg). Inclusion of either blood product improved ADG (P < 0.005) and G:F (P < 0.001) compared to pigs fed the control diet without added blood products. However, pigs fed spray-dried blood meal had greater ADG (P < 0.001), ADFI (P < 0.04), and G:F (P < 0.001) from d 0 to 7 compared to those fed blood cells. The greatest differences observed between the two blood products occurred at the 5 and 7.5% inclusion levels. No differences (P > 0.05) in growth performance were detected between the two blood products from d 7 to 14. In Exp. 2, 380 barrows (initial BW of 10.7 kg and 41 +/- 2 d of age) were used to determine lysine bioavailability of spray-dried blood meal and blood cells via the slope ratio procedure. With G:F ratio as the response criterion, blood meal and blood cells had similar lysine bioavailability relative to crystalline lysine. These experiments indicate that both blood products had similar lysine bioavailability, and that pigs fed spray-dried blood meal had greater performance during the initial 7 d (d 5 to 12 after weaning). However, as the pigs became heavier, there were no differences observed in performance of pigs fed either blood meal or blood cells.