Rapid defunctionalization of carbonyl group to methylene with polymethylhydrosiloxane-B(C(6)F(5))(3)

S Chandrasekhar; Ch Raji Reddy; B Nagendra Babu

doi:10.1021/jo0204045

Rapid defunctionalization of carbonyl group to methylene with polymethylhydrosiloxane-B(C(6)F(5))(3)

J Org Chem. 2002 Dec 13;67(25):9080-2. doi: 10.1021/jo0204045.

Authors

S Chandrasekhar¹, Ch Raji Reddy, B Nagendra Babu

Affiliation

¹ Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India. [email protected]

PMID: 12467433
DOI: 10.1021/jo0204045

Abstract

The polymethylhydrosiloxane-B(C(6)F(5))(3) combination is found to be a versatile carbonyl defunctionalization system under mild and rapid conditions. For the first time, B(C(6)F(5))(3) has been used as a nonconventional Lewis acid catalyst to activate PMHS. Aromatic and aliphatic carbonyl compounds were effectively reduced to give the corresponding alkanes in high yields.