Abstract
Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Benzophenones / chemical synthesis*
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Benzophenones / pharmacology
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Bibenzyls / chemistry
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Cell Cycle / drug effects
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Crystallography, X-Ray
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Drug Resistance, Multiple
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Models, Molecular
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Molecular Structure
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Stilbenes*
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Benzophenones
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Bibenzyls
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Stilbenes
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combretastatin