Numerous studies have demonstrated an age-related decline in episodic memory performance. However, both younger and older adults benefit from various kinds of encoding support, suggesting that memory functioning remains plastic in older age. The present review is concerned with encoding support in the form of enactment. Memory for simple commands is substantially higher if the commands are enacted during encoding than only read/heard. Such memory enhancement has been demonstrated for many age groups and patient groups, suggesting that it is a general effect. Analysis of the results from 1000 participants ranging in age between 35 and 80 years revealed that about 5% of the participants had low memory performance after enacted encoding and showed no enactment effect. The majority of these were older. Comparisons of participants that did or did not show an enactment effect for a select set of biological and neuropsychological factors provided tentative evidence that a failure to benefit from encoding enactment reflects a dysfunctional motor system. This is in agreement with findings from recent functional neuroimaging studies that associate the enactment effect with motor areas in the brain. Variation in the ability to benefit from encoding enactment is discussed in relation to an age-related decline in dopamine function.