Abstract
Foreign environments may induce adult stem cells to switch lineages and populate multiple tissue types, but whether this mechanism is used for tissue repair remains uncertain. Urodele amphibians can regenerate fully functional, multitissue structures including the limb and tail. To determine whether lineage switching is an integral feature of this regeneration, we followed individual spinal cord cells live during tail regeneration in the axolotl. Spinal cord cells frequently migrate into surrounding tissue to form regenerating muscle and cartilage. Thus, in axolotls, cells switch lineage during a real example of regeneration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ambystoma / physiology
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Animals
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Cell Differentiation
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Cell Lineage*
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Cell Movement
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Chondrocytes / cytology*
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Chondrocytes / physiology
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Ectoderm / cytology
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Glial Fibrillary Acidic Protein / genetics
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Green Fluorescent Proteins
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Luminescent Proteins / genetics
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Mesoderm / cytology
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Muscle Cells / cytology*
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Muscle Cells / physiology
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Neuroglia / physiology
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Neurons / cytology
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Neurons / physiology
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Regeneration*
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Spinal Cord / cytology*
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Spinal Cord / physiology
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Stem Cells / physiology*
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Tail / physiology
Substances
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Glial Fibrillary Acidic Protein
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Luminescent Proteins
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Green Fluorescent Proteins