Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A. flavicollis in nature

J Virol. 2003 Jan;77(1):804-9. doi: 10.1128/jvi.77.1.804-809.2003.

Abstract

Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa strains which fell into two distinct genetic lineages. Molecular phylogenetic analyses gave evidence for genetic reassortment between S and M segments of DOBV-Af and DOBV-Aa and indicated homologous recombination events in DOBV evolution. DOBV-Af and DOBV-Aa are distinct but also subject to genetic exchanges that affect their evolutionary trajectories.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Molecular Sequence Data
  • Muridae / virology*
  • Orthohantavirus / classification*
  • Orthohantavirus / genetics*
  • Phylogeny
  • Reassortant Viruses / genetics
  • Recombination, Genetic

Associated data

  • GENBANK/AY168576
  • GENBANK/AY168577
  • GENBANK/AY168578