The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: discovery of a new method to generate cis-propenyl amides

Angew Chem Int Ed Engl. 2002 Feb 1;41(3):512-5. doi: 10.1002/1521-3773(20020201)41:3<512::aid-anie512>3.0.co;2-r.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amides / chemistry*
  • Cysteine Endopeptidases
  • Molecular Structure
  • Multienzyme Complexes / antagonists & inhibitors*
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology
  • Proteasome Endopeptidase Complex
  • Stereoisomerism

Substances

  • Amides
  • Multienzyme Complexes
  • Peptides, Cyclic
  • TMC-95A
  • TMC-95B
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex