Abstract
We evaluated the incidence of FLT3/internal tandem duplication (ITD) mutation in childhood acute myeloid leukaemia (AML) diagnosed over 15 years. FLT3/ITD was found in 10 of 45 (22.2%) non-acute promyelocytic leukaemia (non-APL) patients. The 5-year event-free survival of non-APL patients was higher in FLT3/ITD-negative versus -positive patients (48.9%, SE 8.9, vs 20.0%, SE 16.1, P = 0.03). In childhood APL, FLT3/ITD incidence was higher than in non-APL, although not statistically significant (10 out of 29 patients, 34.5%, P = 0.29). In APL patients, FLT3/ITD was strongly correlated to a higher white blood cell count at diagnosis and the M3 French-American-British subtype.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Child
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Child, Preschool
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Disease-Free Survival
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Female
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Gene Duplication
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Humans
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Infant
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Leukemia, Myeloid, Acute / genetics*
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Leukemia, Myeloid, Acute / immunology
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Leukemia, Myeloid, Acute / mortality
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Leukemia, Promyelocytic, Acute / genetics
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Leukemia, Promyelocytic, Acute / immunology
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Leukemia, Promyelocytic, Acute / mortality
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Leukocyte Count
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Male
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Polymerase Chain Reaction / methods
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Prognosis
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Proto-Oncogene Proteins / genetics*
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Receptor Protein-Tyrosine Kinases / genetics*
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Tandem Repeat Sequences*
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fms-Like Tyrosine Kinase 3
Substances
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Proto-Oncogene Proteins
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FLT3 protein, human
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Receptor Protein-Tyrosine Kinases
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fms-Like Tyrosine Kinase 3