Abstract
We have cloned and characterized the kex1 gene of Pneumocystis jiroveci. Unlike the case for Pneumocystis carinii, in which the homologous PRT-1 genes are multicopy, kex1 is a single-copy gene encoding a protein homologous to fungal serine endoproteases, which localize to the Golgi apparatus. Thus, substantial biological differences can be seen among Pneumocystis species.
MeSH terms
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Amino Acid Sequence
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Ascomycota / enzymology*
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Ascomycota / genetics
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Fungal Proteins / chemistry
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Gene Dosage*
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Molecular Sequence Data
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Proprotein Convertases*
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Saccharomyces cerevisiae Proteins*
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Sequence Analysis, DNA
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Serine Endopeptidases / chemistry
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Serine Endopeptidases / genetics*
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Serine Endopeptidases / metabolism
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Subtilisins / chemistry
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Subtilisins / genetics*
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Subtilisins / metabolism
Substances
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Fungal Proteins
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Saccharomyces cerevisiae Proteins
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Kex1 protein, Pneumocystis jirovecii
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Proprotein Convertases
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Serine Endopeptidases
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Subtilisins
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KEX2 protein, S cerevisiae
Associated data
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GENBANK/AY127566
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GENBANK/AY130996