Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei

Sodngam Sirirath; Junichi Tanaka; Ikuko I Ohtani; Toshio Ichiba; Rachmaniar Rachmat; Kazunori Ueda; Takeo Usui; Hiroyuki Osada; Tatsuo Higa

doi:10.1021/np0200865

Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei

J Nat Prod. 2002 Dec;65(12):1820-3. doi: 10.1021/np0200865.

Authors

Sodngam Sirirath¹, Junichi Tanaka, Ikuko I Ohtani, Toshio Ichiba, Rachmaniar Rachmat, Kazunori Ueda, Takeo Usui, Hiroyuki Osada, Tatsuo Higa

Affiliation

¹ Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

PMID: 12502321
DOI: 10.1021/np0200865

Abstract

Six new polyketides, bitungolides A-F (1-6), have been isolated from the Indonesian sponge Theonella cf. swinhoei and their structures elucidated by spectroscopic data and X-ray diffraction analysis. The bitungolides are a new class of Theonella metabolites that inhibit dual-specificity phosphatase VHR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dose-Response Relationship, Drug
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Indonesia
Microtubules / drug effects
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Phosphoric Monoester Hydrolases / antagonists & inhibitors*
Porifera / chemistry*
Pyrones / chemistry
Pyrones / isolation & purification*
Pyrones / pharmacology
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction

Substances

Enzyme Inhibitors
Pyrones
pironetin
Phosphoric Monoester Hydrolases