Abstract
A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against challenge with a virulent PPRV strain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animal Diseases / prevention & control*
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Animals
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Base Sequence
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Capripoxvirus / immunology
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Capripoxvirus / isolation & purification*
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DNA Primers
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DNA, Complementary
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Dose-Response Relationship, Immunologic
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Peste-des-Petits-Ruminants / prevention & control*
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Peste-des-Petits-Ruminants / veterinary
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Peste-des-petits-ruminants virus / immunology
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Poxviridae Infections / prevention & control*
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Poxviridae Infections / veterinary
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Poxviridae Infections / virology
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Ruminants
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Viral Vaccines / administration & dosage
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Viral Vaccines / immunology*
Substances
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DNA Primers
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DNA, Complementary
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Viral Vaccines