[New tactics of human red blood cells stored at 4 degrees C-protective effect of antioxidant solution on red blood cells damage]

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002 Apr;10(2):153-5.
[Article in Chinese]

Abstract

Aliquots of venous blood from healthy donor were collected in plastic blood storage bags with ACD, GMA or antioxidant solution (superoxide dismutase, SOD), respectively, and stored at 4 degrees C. After storage for varying periods, the parameters of the blood were detected in the blood samples. Results showed that the parameters of the blood stored at 4 degrees C for 75 days in SOD group were following: the recovery of RBC-Hb was 87.2%, plasma-Hb (mg/L) was 193.2, P50 (mmHg) was 34.0 (normal value was 33.1); deformability (DImax) was 0.2413 (74.3% of normal value). There was no evident hemolysis, color change, air bubble and clots. It was concluded that human RBC stored at 4 degrees C for 75 days with SOD solution, recovery of levels of RBC-Hb and plasma-Hb were accorded with the requirements of "Basic Demands of Blood Station" in China.

Publication types

  • English Abstract

MeSH terms

  • Antioxidants / pharmacology*
  • Blood Preservation / methods*
  • Cold Temperature*
  • Erythrocyte Deformability / drug effects
  • Erythrocytes / drug effects*
  • Erythrocytes / metabolism
  • Free Radical Scavengers / pharmacology
  • Hemoglobins / drug effects
  • Hemoglobins / metabolism
  • Humans
  • Superoxide Dismutase / pharmacology
  • Time Factors

Substances

  • Antioxidants
  • Free Radical Scavengers
  • Hemoglobins
  • Superoxide Dismutase