Abstract
In recent years it has become apparent that the long-term survival of T cells requires continuous contact with external stimuli. At least two types of stimuli, namely self antigens and cytokines, are involved in maintaining T cell viability. As discussed here, the factors controlling T cell survival and turnover in vivo differ considerably from one T cell subset to another.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Division / immunology
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Cell Survival
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Cytokines / immunology*
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Homeostasis
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Humans
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Immunologic Memory / physiology
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Interleukins / metabolism*
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Lymphocyte Activation
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Major Histocompatibility Complex / immunology
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Receptors, Antigen, T-Cell / metabolism*
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T-Lymphocytes / physiology*
Substances
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Cytokines
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Interleukins
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Receptors, Antigen, T-Cell