Synthesis of an amino-functionalized model of the Fe-only hydrogenase active site

Chemistry. 2003 Jan 20;9(2):557-60. doi: 10.1002/chem.200390058.

Abstract

A dinuclear 2Fe2S mimic 6 of the active site of the Fe-only hydrogenases has been synthesized. Complex 6 contains a free amino group which enables linkage to a protein backbone or to a redox active species for the study of electron transfer processes in proteins or in supramolecular systems. The structures of the complex 6 and its Boc-protected precursor 5 could be verified by X-ray crystallography.

MeSH terms

  • Amines / chemistry*
  • Binding Sites
  • Hydrogenase / chemical synthesis*
  • Hydrogenase / chemistry*
  • Hydrogenase / metabolism
  • Iron / metabolism*
  • Models, Molecular
  • Molecular Mimicry*
  • Molecular Structure
  • Oxidation-Reduction

Substances

  • Amines
  • Iron
  • Hydrogenase