Selective, catalytic carbon-carbon bond activation and functionalization promoted by late transition metal catalysts

J Am Chem Soc. 2003 Jan 29;125(4):886-7. doi: 10.1021/ja028912j.

Abstract

The selective catalytic activation and functionalization of carbon-carbon bonds in a series of substituted cyclopropane substrates has been developed using commercially available transition metal catalysts. Catalytic hydrogenation and olefination procedures, tolerant of a range of functional groups, have been discovered. Introduction of a chelate-assisting substituent such as [PPh2] is effective in altering the kinetic selectivity and lowering the activation barrier for the catalytic processes.