Objective: Porphyromonas gingivalis (Pg) is one of the main putative pathogens of periodontal disease, especially of adult periodontitis. This in vitro study was aimed at observing the inhibitory activities of 7 commonly used antimicrobical drugs on 106 stains of Pg which isolated from subgingival plaques of sites with adult periodontits.
Methods: Kirby-Bauer paper disk method was used in this study.
Results: Pg was highly susceptible to Clindamycin, Sulfamzthoxazole timethoprin, Tetracycline and Cefazolin, the susceptibility rates were 93.4%, 78.3%, 60.4% and 56.6% respectively.
Conclusion: Majority of the strains of Pg was moderately susceptible to cefalexin and acetylspiramycin, while no strains of Pg was susceptible to Penicillin G. The concentrations of Pg solutions (10(5) CFU/ml, 10(6) CFU/ml and 10(8) CFU/ml) had not influence on the results. This data is helpful for clinically antibiotic selection of periodontal treatment.