Objective: To study the clinical effect of capsaicin of nasal administration in 100 cases of allergic rhinitis.
Method: Capsaicin was applied by nostril, once 5 days and 5 times as a therapeutic course. Acidophil were measured and nasal airflow resistance was analysed before and after capsaicin therapy.
Result: It showed that nasal symptoms of patients were obviously relieved and 94% of the cases in the measure of acidophil changed to negative from positive. Moreover, capsaicin induced decrease in nasal airflow resistance from (0.6272 +/- 0.3534) kPa.s/L before therapy to (0.4057 +/- 0.2419) kPa.s/L after therapy (P < 0.001). 90 cases of 100 patients were fellowed up one year, the total effective rate was 89%.
Conclusion: Our study suggests that capsaicin possessed remarkable effects in the treatment of allergic rhinitis; analyse of nasal airflow resistance may be used as one of the objective guideline in the determinant of therapeutic effects.