Abstract
From the marine sponge Xestospongia exigua collected in Indonesia the fungus Aspergillus versicolor was isolated. Following cultivation in a seawater-based medium seven new angular tricyclic chromone derivatives (1-7) were obtained from the mycelia and culture filtrate. Compounds 2-7 contain an additional dihydropyran ring system which is replaced by a pyridine ring in 1. The structures of the new natural products were established on the basis of extensive one- and two-dimensional NMR spectroscopic studies (1H, 13C, COSY, HMQC, HMBC, NOE difference spectra) as well as on mass spectral analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Aspergillus / chemistry*
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Bacillus subtilis / drug effects
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Chromones / chemistry
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Chromones / isolation & purification*
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Chromones / pharmacology
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Cyclization
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Escherichia coli / drug effects
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Heterocyclic Compounds, 3-Ring / chemistry
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Heterocyclic Compounds, 3-Ring / isolation & purification*
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Heterocyclic Compounds, 3-Ring / pharmacology
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Indonesia
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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Saccharomyces cerevisiae / drug effects
Substances
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Anti-Bacterial Agents
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Chromones
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Heterocyclic Compounds, 3-Ring
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aspergillitine