Abstract
Three new cyclic diarylheptanoids, acerosides B1 and B2 and aceroketoside, were isolated together with 20 known compounds from a Japanese folk medicine, the stem bark of Acer nikoense. The absolute stereostructures of the new compounds were determined on the basis of chemical and physicochemical evidence. In addition, the principal diarylheptanoid constituents were found to exhibit inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages.
MeSH terms
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Acer / chemistry*
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Animals
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Diarylheptanoids / chemistry
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Diarylheptanoids / isolation & purification*
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Diarylheptanoids / pharmacology
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Hydrolysis
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Japan
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Medicine, Traditional
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Mice
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Stereoisomerism
Substances
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Diarylheptanoids
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Lipopolysaccharides
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aceroketoside
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aceroside B1
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aceroside B2
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Nitric Oxide