Abstract
One critical step of apoptosis is the release of mitochondrial proteins through the outer mitochondrial membrane. Recent work shows that two pro-apoptotic Bcl-2 family proteins, Bax and Bid, as well as the mitochondrion-specific lipid cardiolipin may cooperate in chemically defined liposomes to generate a protein-permeable conduit, relaunching the debate on the identity of the pore responsible for mitochondrial membrane permeabilization during apoptosis.
MeSH terms
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Animals
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Apoptosis / physiology*
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BH3 Interacting Domain Death Agonist Protein
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Cardiolipins / metabolism
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Carrier Proteins / metabolism
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Caspases / metabolism
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In Vitro Techniques
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Intracellular Membranes / metabolism
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Matrix Metalloproteinases / metabolism
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Mitochondria / metabolism*
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Models, Biological
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Permeability
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-bcl-2*
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bcl-2-Associated X Protein
Substances
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BH3 Interacting Domain Death Agonist Protein
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Cardiolipins
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Carrier Proteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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bcl-2-Associated X Protein
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Caspases
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Matrix Metalloproteinases