Abstract
Proteins may serve as ideal CD8(+) T cell immunogens for human immunodeficiency virus type 1 (HIV-1) if they can be delivered to and processed through the human leukocyte antigen class I pathway. This study shows that human blood monocyte-derived dendritic cells loaded with liposome-complexed HIV-1 proteins and matured with CD40 ligand can prime CD8(+) T cells to HIV-1 in vitro. Whole HIV-1 protein in liposome may be an effective immunogen for HIV-1 vaccine protocols.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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AIDS Vaccines / administration & dosage
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AIDS Vaccines / immunology
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CD40 Ligand
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CD8-Positive T-Lymphocytes / immunology*
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Cell Membrane
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Cells, Cultured
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Dendritic Cells / immunology*
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Dendritic Cells / virology*
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HIV Antigens / administration & dosage
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HIV Antigens / immunology*
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HIV-1 / immunology*
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Humans
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Liposomes
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Lymphocyte Activation*
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Phosphatidylethanolamines
Substances
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AIDS Vaccines
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HIV Antigens
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Liposomes
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Phosphatidylethanolamines
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CD40 Ligand
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1,2-dielaidoylphosphatidylethanolamine