This report focuses on a 16-year-old girl afflicted with hypoglycemia after administration of medications for gastrointestinal symptoms. Repaglinide-induced hypoglycemia was suspected when a tablet of repaglinide was noted in the drug package that she had been given. As the use of various types of oral hypoglycemic agents has increased, a definitive diagnosis of drug-induced hypoglycemia has become difficult. It is dangerous for a patient to take oral hypoglycemic agents without the knowledge of hypoglycemic symptoms and initial management. We present this case and review the characteristics of repaglinide to remind physicians and pharmacists to pay more attention to this situation.