Regression of refractory rhabdomyosarcoma after allogeneic stem-cell transplantation

Pediatr Hematol Oncol. 2003 Mar;20(2):151-5. doi: 10.1080/0880010390158658.

Abstract

A 17-year-old girl developed refractory rhabdomyosarcoma. An allogeneic peripheral-blood stem-cell transplant was performed after a myeloablative regimen. Although rapid disease progression had resolved transiently, after the start of high-dose chemotherapy, re-progression was apparently observed from day 14. However, delayed tumor regression occurred on day 30, shortly after the reduction of immunosuppressants. She achieved a partial remission. The second tumor regression provides suggestive clinical evidence that graft-versus-tumor effect may occur against rhabdomyosarcoma. Although further investigation is required, allogeneic stem-cell transplantation could provide a new therapeutic option for refractory rhabdomyosarcoma.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Agents, Alkylating / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Dactinomycin / administration & dosage
  • Disease Progression
  • Doxorubicin / administration & dosage
  • Doxorubicin / analogs & derivatives*
  • Drug Resistance, Neoplasm
  • Etoposide / administration & dosage
  • Fatal Outcome
  • Female
  • Graft vs Tumor Effect
  • Head and Neck Neoplasms / drug therapy
  • Head and Neck Neoplasms / radiotherapy
  • Head and Neck Neoplasms / therapy*
  • Humans
  • Ifosfamide / administration & dosage
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use
  • Neoplasm Recurrence, Local
  • Nimustine / therapeutic use
  • Peripheral Blood Stem Cell Transplantation*
  • Rhabdomyosarcoma / drug therapy
  • Rhabdomyosarcoma / radiotherapy
  • Rhabdomyosarcoma / therapy*
  • Transplantation Conditioning
  • Vincristine / administration & dosage

Substances

  • Antineoplastic Agents, Alkylating
  • Immunosuppressive Agents
  • Nimustine
  • Dactinomycin
  • Vincristine
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • pirarubicin
  • Cisplatin
  • Ifosfamide