We report a case of infectious endocarditis from Staphylococcus epidermidis that occurred early after mitral valve repair (one month), suggested by fever of 38.5 degrees C and valvular vegetations of less than 10 mm on the mitral valve. In the absence of standard recommendations (medical or surgical) in treating patients with infectious endocarditis occurring after mitral valve repair, and in the absence of complications, a medical regimen was chosen associating aspirin (anti-aggregant dosages) with antibiotics. The benefit of aspirin in endocarditis has been demonstrated in experimental studies with regards to valvular vegetations and embolic risk but remains to be studied in human clinical trials. With the association of aspirin (100 mg/d) and triple antibiotic therapy (rifampicin 1200 mg/d, vancomycin 2 g/d, gentamycin 180 mg/d), the clinical status improved with complete regression of vegetations in less than 24 days and the absence of recurrence at one-year follow-up.