[Expression of genes aroG and pheA in phenylalanine biosynthesis]

Wei Sheng Wu Xue Bao. 1999 Oct;39(5):430-5.
[Article in Chinese]

Abstract

aroG and pheA genes, encoding 3-Deoxy-D-arabinoheptulonate-7-phosphate synthase(DS) and Chorismate mutase (CM)-prephenate dehydratase(PD) in the pathway of phenylalanine biosynthesis respectively, were amplified by polymerase chain reaction(PCR). The genes were assembled on the multicopy vectors and expressed in both Escherichia coli and Brevibacterium. The products of two gene were detected by SDS-PAGE. The activities of relevant enzymes were measured in the crude extract of the host strain. When aroG-pheA genes were introduced into E. coli p2392, the activities of DS, CM and PD were increased by 4.3-fold, 4.4-fold and 2.2-fold respectively. Whereas in the case of Brevibacterium flavum 2732, the activities of DS, CM and PD were increased by 12.3-fold, 2.3-fold and 5.6-fold, respectively. As the results, the overproduction of phenylalanine was brought about by using the genetic engineering strain of B. flavum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Deoxy-7-Phosphoheptulonate Synthase / genetics*
  • 3-Deoxy-7-Phosphoheptulonate Synthase / metabolism
  • Brevibacterium / genetics
  • Chorismate Mutase / genetics*
  • Chorismate Mutase / metabolism
  • Cloning, Molecular
  • Escherichia coli / genetics
  • Gene Expression
  • Genetic Engineering
  • Phenylalanine / biosynthesis*
  • Prephenate Dehydratase / genetics*
  • Prephenate Dehydratase / metabolism

Substances

  • Phenylalanine
  • 3-Deoxy-7-Phosphoheptulonate Synthase
  • Prephenate Dehydratase
  • Chorismate Mutase