[Two patients with distant metastases from head and neck squamous cell carcinomas successfully treated with docetaxel and cisplatin]

Kenji Okami; Akihiro Sakai; Junichi Onuki; Kyoko Odagiri; Masahiro Takahashi

[Two patients with distant metastases from head and neck squamous cell carcinomas successfully treated with docetaxel and cisplatin]

Gan To Kagaku Ryoho. 2003 Jan;30(1):95-9.

[Article in Japanese]

Authors

Kenji Okami¹, Akihiro Sakai, Junichi Onuki, Kyoko Odagiri, Masahiro Takahashi

Affiliation

¹ Dept. of Otolaryngology, Tokai University School of Medicine.

PMID: 12557711

Abstract

Two cases of distant metastases from head and neck squamous cell carcinomas are reported. The patients were treated intravenously with docetaxel (60 mg/m2) in combination with cisplatin (70 mg/m2). The chemotherapy was repeated every three weeks. Both cases showed a remarkable response. A complete response was obtained in one case. Grade 1 nausea and alopecia were observed. One patient had grade 3 neutropenia, which was treated with G-CSF. We herein describe the efficacy of newly developed docetaxel with cisplatin in treating distant metastasis from head and neck cancer.

Publication types

Case Reports

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carboplatin / administration & dosage
Carcinoma, Squamous Cell / drug therapy*
Carcinoma, Squamous Cell / secondary*
Cisplatin / administration & dosage
Docetaxel
Head and Neck Neoplasms / drug therapy*
Head and Neck Neoplasms / pathology*
Humans
Lung Neoplasms / drug therapy*
Lung Neoplasms / secondary
Male
Middle Aged
Neoplastic Cells, Circulating
Paclitaxel / administration & dosage
Paclitaxel / analogs & derivatives*
Remission Induction
Taxoids*

Substances

Taxoids
Docetaxel
Carboplatin
Paclitaxel
Cisplatin