5,9,23-Triacontatrienoic methyl ester, an elastase inhibitor from the marine sponge Chondrilla nucula

Michèle Meyer; Michèle Guyot

doi:10.1007/s11745-002-1007-y

5,9,23-Triacontatrienoic methyl ester, an elastase inhibitor from the marine sponge Chondrilla nucula

Lipids. 2002 Nov;37(11):1109-11. doi: 10.1007/s11745-002-1007-y.

Authors

Michèle Meyer¹, Michèle Guyot

Affiliation

¹ Laboratoire de Chimie, ESA 8041 C.N.R.S., Muséum National d'Histoire Naturelle, F-75005 Paris, France.

PMID: 12558062
DOI: 10.1007/s11745-002-1007-y

Abstract

A polyethylenic fatty ester was isolated from the marine sponge Chondrilla nucula. The structure was elucidated through NMR spectral data and MS analysis as 5,9,23-triacontatrienoic methyl ester 1. Compound 1 is an elastase inhibitor [ID50 = 10 microg/mL (2 x 10(-5) M)].

MeSH terms

Animals
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Fatty Acids, Unsaturated / chemistry
Fatty Acids, Unsaturated / isolation & purification*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Pancreatic Elastase / antagonists & inhibitors*
Porifera / chemistry*

Substances

5,9,23-triacontatrienoic methyl ester
Enzyme Inhibitors
Fatty Acids, Unsaturated
Pancreatic Elastase